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Other than being involved in dietary lipid emulsion and adsorption, once they have reached the small intestine, primary bile acids are processed and metabolized into secondary bile acids by intestinal microbial enzymatic activity [206]: such biotransformations are mainly represented by deamination (or deconjugation), carried by the Bile Salt Hydrolase (BSH) abundantly expressed by Lactobacillus , Bifidobacterium , Enterococcus and Clostridium species [207], and epimerization, carried out by hydroxysteroid dehydrogenases (HSDHs) [208]

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Currently, one medication that targets B-cell activity—belimumab—is approved

It also plays a key role in the immune system